There's usually one or two answers you can rule out immediately. After that an educated guess takes you a long way
The advice to "when in doubt, pick B" may be a result of middle bias. This bias may also improve the readability of quizzes.
Some say that B and E are the most likely answers in multiple-choice questions with four and five options, respectively. Others say that the best strategy is to pick a favorite letter and use it for every guess.
10 Things I Hate About You, 12 Angry Men, Aliens, And Then There Were None, Argylle, Clue, Labyrinth, Langoliers, Krull, Matrix, Private Eyes, Silver Streak, The Game, The Greatest Showman, The Mummy, The Princess Bride, Willow